Plasma fluctuation in estradiol-17β and bone resorption markers around parturition in dairy cows

نویسندگان

  • Bhuminad DEVKOTA
  • Masahiro TAKAHASHI
  • Saori SATO
  • Kouya SASAKI
  • Atsushi UEKI
  • Takeshi OSAWA
  • Norio YAMAGISHI
چکیده

Blood samples were obtained sequentially from 10 dairy cows around the time of parturition to assess plasma fluctuations in estradiol-17β (E2) levels in association with those of several bone resorption markers. Plasma E2 concentration increased sharply a few days prepartum and decreased quickly after parturition. In terms of bone resorption markers, the plasma level of tartrate-resistant acid phosphatase isoform 5b (TRAP5b) rose significantly, commencing 1 week prepartum, and was maintained at this level to a few days postpartum. The plasma concentration of carboxyterminal collagen cross-links of type-I collagen (CTx) increased significantly after parturition. These observations suggest that osteoclast-mediated bone resorption was activated after parturition when plasma E2 concentrations decreased.

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عنوان ژورنال:

دوره 77  شماره 

صفحات  -

تاریخ انتشار 2015